La línea de productos PEVIVA fue inventada en el Instituto Karolinska en Estocolmo, y se basa en anticuerpos únicos que miden la apoptosis y la muerte total de células.
Desde la invención, los productos se han utilizado a nivel mundial en la academia, la industria y en la atención sanitaria.
La apoptosis es un mecanismo de muerte celular programado y controlado que se activa por estímulos intracelulares o extracelulares.
The M30 Apoptosense® ELISA measures the amount of human apoptosis by quantifying the concentration of caspase-cleaved keratin 18 (ccK18).
The assay is based on the unique M30 antibody that recognizes a neo-epitope of keratin 18 (K18), formed after caspase cleavage during apoptosis. The assay can be combined with the M65® ELISA for the analysis of cell death mode (necrosis or apoptosis).
The M30 Apoptosense® ELISA is CE marked as a medical device for in vitro diagnostic use.
The M30 CytoDeath™ ELISA offers a unique possibility to measure human cell death by apoptosis in cell cultures, multicellular spheroids and organ culture systems.
The M30 CytoDeath™ ELISA is a product developed for cell culture applications, with a dynamic range and sensitivity suitable for in vitro work, making it a useful drug screening tool.
El M65® ELISA y el M65 EpiDeath® ELISA, ambos basados en los anticuerpos únicos M5 y M6, cuantifican los niveles totales de K18 soluble y así miden la cantidad de muerte celular total por cualquier causa.
The M65® ELISA measures total cell death due to apoptosis or necrosis by quantifying the levels of total soluble keratin 18 (K18) released from dying cells.
The assay, based on the M5 and the M6 antibodies, is intended for human serum or plasma, and is CE marked as a medical device for in vitro diagnostic use.
The M65 EpiDeath® ELISA measures the concentration of total soluble keratin 18 (K18) in human plasma, serum and cell culture supernatants. The K18 levels reflect the amount of total cell death, due to apoptosis or necrosis.
The M65 EpiDeath® ELISA represents the next generation of K18 positive biomarker assays, and is CE marked as a medical device for in vitro diagnostic use.
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